Generation 0 And 1 – Breast Density Study

We are now inviting our Raine Study Mothers and Grandmothers of our Gen2 cohort to be part of this study.    

In the 27 year follow up at the Raine Study House a breast density scan was undertaken on all Gen2 females using a device called TiBS (Transillumination Breast Spectroscopy). TiBS can determine how much fatty tissue and how much dense tissue there is in breasts, and increased breast density is a strong risk factor for breast cancer in older women (typically >40 years of age) but little is known about breast density in younger women.

The reasons for differences in breast density are largely thought to be genetic but there are also lifestyle factors that may cause breasts to become denser or fattier.

What is the aim of this study?

We now want to make the TiBS breast density measurement more user friendly and want to estimate the population distribution of TiBS breast density in women of different ages.

To do this, we would like to

  • Measure your breast density using TiBS and to obtain a copy of your mammogram (if available) to measure your mammographic breast density for comparison purposes.
  • If you have attended BreastScreen WA, we would like your permission to obtain a copy of your mammogram on your behalf (you do not need to contact BreastScreen WA).
  • We also want to obtain a blood sample to estimate the heritability of TiBS scores within families and its association with known genetic determinants of mammographic breast density.

What will the appointment involve?

You will be required to attend a 60-minute appointment at Raine Study house located at the University of Western Australia, Crawley Campus. At your appointment you will be given an opportunity to ask any questions you may have about this study. You will be asked to sign a consent form for your permission to link information held in other datasets to the Raine Study data.  A trained research assistant will then:

  1. Take your height, weight and resting blood pressure
  2. Ask you to complete a questionnaire on a number of lifestyle factors like; work history, oral contraceptive use, alcohol use, reproductive history, family history of breast cancer
  3. Take a DNA blood sample (if you have not previously provided DNA for the RaineStudy)
  4. Do a breast scan using the TiBS device.

Book your appointment

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