Developmental origins of psycho-cardiometabolic multimorbidity in adolescence and their underlying pathways through methylation markers: a two-cohort study

Choudhary P, Ronkainen J, Carson J, Karhunen V. Lin A, Melton PE, Jarvelin MR, Miettunen J, Huang RC, Sebert S. 17 Feb 2024 European Child & Adolescent Psychiatry. doi: 10.1007/s00787-024-02390-1

Publication date: 17 Feb 2024

Keywords: adolescents, DNA methylation age, epigenetics, Multimorbidity, Psycho-cardiometabolic

What is already known about this subject:

  • Understanding the biological mechanisms behind multimorbidity patterns in adolescence is important as they may act as intermediary risk factor for long-term health.
  • We aimed to explore relationship between prenatal exposures and adolescent's psycho-cardiometabolic intermediary traits mediated through epigenetic biomarkers, using structural equation modeling (SEM).

What this study adds

  • The present study exemplifies an evidence-based approach in two different birth cohorts to demonstrate similar composite structure of prenatal exposures and psycho-cardiometabolic traits (despite cultural, social, and genetic differences) and a common plausible pathway between them through underlying epigenetic markers.
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Areas of Interest