Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

Guirette M, Lan J, McKeown NM, Brown MR, Chen H, de Vries PS, Kim H, Rebholz CM, Morrison AC., Bartz TM, Fretts AM, Guo X, Lemaitre RN, Liu CT, Noordam R, de Mutsert R, Rosendaal FR, Wang CA, Beilin LJ, Mori TA, Oddy WH, Pennell CE, Chai JF, Whitton C, van Dam RM, Liu J, Tai ES, Sim X, Neuhouser ML, Kooperberg C, Tinker LF, Franceschini N, Huan T, Winkler TW, Bentley AR, Gauderman WJ, Heerkens L, Tanaka T, van Rooij J, Munroe PJ, Warren HR, Voortman T, Chen H, Rao DC, Levy D, Ma J. C. G.-L. I. W. Group 16 Jan 2024 Hypertension. doi: 10.1161/HYPERTENSIONAHA.123.22334

Publication date: 16 Jan 2024

Keywords: DASH Diet Score, DNA methylation levels, Genome-Wide Interaction Analysis, genotype interaction, Systolic Blood Pressure

What is already known about this subject:

The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.

What this study adds

By examining gene-Dietary Approach to Stop Hypertension (DASH) diet score interaction, our study identified novel genetic loci affecting blood pressure (BP) and provided new insights into the mechanisms linking the DASH diet and BP.
At the MTHFS (methenyltetrahydrofolate synthetase) locus (15q25.1), we showed that the interaction between the DASH diet score and genetic variants may affect DNA methylation levels and subsequently change systolic BP.
Studies with larger diverse populations are needed to validate our findings.

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Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure

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