The Raine Study is a rich resource for researchers.
The Raine Study is one of the most comprehensive pregnancy birth cohort studies in the world. It is a rich resource for the study of environmental and genetic factors that affect health and development and can provide unique insights into the natural history of human diseases. Between May 1989 and November 1991, 2900 pregnant women were recruited into the study and their children have been assessed intensively over the past three decades.
Prospective longitudinal data has been collected at multiple time-points over pregnancy, infancy, childhood, adolescence and young adulthood and there is broad multidisciplinary data on physical, mental and social aspects of development.
The main cohort (Gen2) are now almost 30 years of age and maintain a keen sense of commitment to the Raine Study. Their data has been genotyped and data linkage with other publicly held datasets (e.g. school results and hospital records) is available. There are stored biological samples and established collaborative research networks across a wide variety of disciplines.
Multigenerational lifecourse study
The Raine Study is now a multigenerational lifecourse study addressing a broad range of health and developmental issues in four generations. In addition to the original cohort (Gen2), their parents (Gen1) participated in assessments, providing information about their children and about themselves. Gen1 has recently participated in assessments of sleep, obesity and activity. In addition, the offspring (Gen3) of the original cohort (Gen2) is currently participating in assessments of developmental ability and physical activity. We are currently also conducting a study involving the Grandparents (Gen0).
Current areas of research
There are currently more than 150 researchers utilising the Raine Study. The investigators bring expertise from 25 broad areas of research including; asthma and atopy, cardiovascular and metabolic heath, childhood developmental growth, dental health, diabetes, genetic epidemiology, gastro-enterology, infection and immunity, mental health, musculoskeletal development, nutrition, physical activity, ophthalmology, pregnancy and birth, reproductive health, sleep and risk taking behaviour.
National and international research collaborations with the Raine Study are extensive and continuing to develop which value adds to the cohort and expands research and funding opportunities.
The future success of the Raine Study is vital as it is now clear that both genes and the environment of mother, baby, child and adolescent are key contributors to diseases and conditions that account for approximately one third of the global burden of disease, in both developed and developing countries. This prospectively collected extensive data resource can assist in unraveling the complex interaction of multiple factors in the pathways to health and disease over the life course.
Working with the Raine Study
The Raine Study is a supported access resource and enquiries are encouraged from researchers who wish to utilise data. Collaboration with existing Raine Study researchers is encouraged and facilitated by the Raine Study Management.
Every new project application goes through a review and approval process that takes on average 6-8 weeks. A project application is first reviewed by the Scientific Management Committee (SMC), which meets on the first and third Wednesday of every month. Following SMC review, the project application is then reviewed by the Scientific Review Committee (SRC), which meets face-to-face once a quarter, with electronic meetings in between as needed.
The process of working with the study is as follows:
For new project applications, we suggest researchers contact the Scientific Management Committee to have an informal discussion about their project idea. The Committee can suggest potential collaborators and advise on relevant considerations, such as data access fees, need for a biosample request, and overlaps with previously approved projects. You can email the Scientific Manager.
The Lead Investigator will submit a Project application via the Raine Online Submission System (ROSS). On ROSS, the project is only formally submitted after each member of the project team confirms their involvement and acknowledge our code of conduct. Once submitted, the application is reviewed during our fortnightly Scientific Management Committee (SMC) meeting. The SMC will discuss the project and then either place the item on the next Scientific Review Committee (SRC) meeting agenda or contact the Lead Investigator to suggest revisions. The SRC will then discuss the project and either approve, request revisions/amendments or reject it. The SRC meets face to face quarterly and electronically in between the face to face meetings. Please allow a period of 6-8 weeks from the formal submission of the project application to final approval.
Projects can only commence once they have received final approval by the Scientific Review Committee and have all required ethics approvals. Every new project proposing to use existing data and/or biosamples or to collect new data and/or biosamples from the Raine Study participants must have its own Human Research Ethics Committee (HREC) approval from a HREC that is registered with the NHMRC. For more information regarding the ethics approval process for projects using the Raine Study resources please refer to the Commonly Used Resources page and FAQ.
For projects involving the use of existing data and/or biosamples, once final approval by the Scientific Review Committee and from a HREC is obtained, the Lead Investigator will submit a data access request and/or biosamples request via ROSS. On ROSS, the data access request is only formally submitted after each listed data handler confirms their involvement and acknowledge our data access code of conduct. Once submitted, the data access request is reviewed during our fortnightly SMC meeting and the SMC will either approve, request revisions/amendments or reject it. If approved, the Raine Study Data and Biosamples Manager will arrange data extraction and secure transfer to the data handlers. Please note the time for data extraction varies according to the amount and type of data requested.
For projects involving the collection of new data and/or biosamples in Raine Study participants, once final approval by the Scientific Review Committee and from a HREC is obtained, the Lead Investigator will work with the Raine Study team to conduct data collection.
This part of the process has three key steps: manuscript proposal, manuscript submission and media release.
The manuscript proposal (MP), i.e. the idea for a manuscript, needs to be submitted in ROSS as early as possible and be related to an approved project. Once submitted, the application is reviewed during our fortnightly SMC meeting. The MP needs to be approved before a manuscript submission (MS) can be completed. The research team then progresses to preparing a full manuscript and once it is almost ready to submit to a journal, must submit the draft manuscript to ROSS using the MS Form. The SMC will then review and approve or advise revisions/amendments are required. Following MS approval, the research team can submit the manuscript to a journal.
Please note manuscripts must not be submitted to a journal prior to the Raine Study approval. Manuscripts will be checked for similarity/plagiarism, potential negative impact on the cohort, and appropriate nomenclature and acknowledgements.
If the team wishes to promote their research through the media, they should contact the Raine Study Communications Manager, who will liaise with the research team and their institutional media team as required and approve any media releases related to the Raine Study.
Raine Online Submission System (ROSS)
ROSS has been designed to provide an efficient project management process and all researchers who would like to use Raine Study data must submit a project application via ROSS. Researchers who would like to get involved in the Raine Study must submit their application via ROSS.
If you do not have a ROSS account, please email the Raine Study.
The Raine Study is registered in the Australian New Zealand Clinical Trials Registry.
Trial ID: ACTRN12617001599369.